What type of enzyme is Thiolase?

Thiolase superfamily is an important class of enzymes that belong to CoA dependent enzyme group. These enzymes are involved in fatty acid biosynthesis by carbon-carbon bond formation via a thioester-dependent Claisen-condensation reaction.

What is the function of enzyme Thiolase?

Thiolases, also known as acetyl-coenzyme A acetyltransferases (ACAT), are enzymes which convert two units of acetyl-CoA to acetoacetyl CoA in the mevalonate pathway.

Which coenzyme takes part in the reaction catalyzed by Thiolase?

Thiolase catalyzes the thiolytic cleavage of 3-ketoacyl-coenzyme A (CoA) to acetyl-CoA and acyl-CoA, and this enzyme is classified into two types by substrate specificity. One type is acetoacetyl-CoA thiolase (EC 2.3.

What is the purpose of CoA?

CoA (coenzyme A) and its derivatives have a critical role in regulating cardiac energy metabolism. This includes a key role as a substrate and product in the energy metabolic pathways, as well as serving as an allosteric regulator of cardiac energy metabolism.

What is the inhibitor of Thiolase?

The most effective inhibitor of 3-ketoacyl-CoA thiolase was found to be 3-keto-4-pentenoyl-CoA, which inhibits the enzyme in both a reversible and irreversible manner.

Where is Thiolase found?

mitochondrion
In eukaryotes, there are two forms of 3-ketoacyl-CoA thiolase: one located in the mitochondrion and the other in peroxisomes.

Is Thiolase used in ketone body degradation?

The enzymes of ketone body degradation are as follows: (1) β-hydroxybutyrate dehydrogenase; (2) Succinyl CoA:acetoacetyl CoA transferase; and (3) Acetoacetyl CoA thiolase. There are several differences in the metabolism of ketone bodies in the kidney and in the liver.

What is CoA enzyme?

Infobox references. Coenzyme A (CoA, SHCoA, CoASH) is a coenzyme, notable for its role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric acid cycle.

What is the role of CoA in cellular respiration?

Acetyl-CoA is an important biochemical molecule in cellular respiration. It is produced in the second step of aerobic respiration after glycolysis and carries the carbon atoms of the acetyl group to the TCA cycle to be oxidized for energy production.

What is lc3 Kat inhibitor?

Trimetazidine acts as an effective antianginal clinical agent by modulating cardiac energy metabolism. Recent published data support the hypothesis that trimetazidine selectively inhibits long-chain 3-ketoacyl CoA thiolase (LC 3-KAT), thereby reducing fatty acid oxidation resulting in clinical benefit.

What is fatty acyl-CoA?

Fatty acyl-CoA synthetase (ACS) catalyzes the adenosine triphosphate dependent formation of a thioester bond between a fatty acid and coenzyme A. This fundamental reaction allows the fatty acid to be degraded for energy production, incorporated into complex lipids, or participate in other metabolic pathways.

What is the inhibitor of thiolase?

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