Which drugs commonly interact with cytochrome P450?
Cytochrome P450 enzymes can be inhibited or induced by drugs, resulting in clinically significant drug-drug interactions that can cause unanticipated adverse reactions or therapeutic failures. Interactions with warfarin, antidepressants, antiepileptic drugs, and statins often involve the cytochrome P450 enzymes.
What is the Flockhart table?
The Flockhart Table(TM) only catalogs drug-drug interactions that are mediated by CYPs. Drug-drug interactions caused via other enzymes (e.g., UGTs) are not included in this table. In addition, some of the drugs listed here could be substrates of uptake and efflux drug transporters.
What medications are metabolized by P450?
Among the drugs metabolized are sedatives such as midazolam, triazolam and diazepam, the antidepressives amitriptyline and imipramine, the anti-arryhthmics amiodarone, quinidine, propafenone and disopyramide, the antihistamines terfenadine, astemizole and loratidine, calcium channel antagonists such as diltiazem and …
What are CYP450 inducers and inhibitors?
Cytochrome P-450 enzyme inducers (e.g., rifampin, phenytoin, phenobarbital) decrease the bioavailability and increase the clearance of verapamil and diltiazem. Conversely, the enzyme inhibitor cimetidine increases the bioavailability and decreases the clearance of calcium antagonists.
How do you remember CYP450 inhibitors?
Cytochrome P450 (CYP450) enzymes can be inhibited or induced by some drugs, resulting in significant drug interactions that can cause unanticipated adverse reactions or therapeutic failures. An easy way to remember the mnemonic is; CRAP GPs spend all day on SICKFACES.com.
How do CYP450 inhibitors work?
CYP450 inhibitors are used to minimize or prevent such reactions. Drugs are metabolized in many sites of our body; however, the liver is the primary organ for drug metabolism. CYP450 inhibition can be categorized as: Reversible inhibition (a result of rapid association and dissociation between drugs and CYP enzymes)
How do you remember CYP interactions?