Does metoclopramide help with migraines?

Conclusion: Metoclopramide is efficacious in the treatment of both the pain and nausea of migraine headache. This is a direct action that is not dependent on the concomitant administration of another agent.

How do you take metoclopramide for migraines?

Take two tablets or two sachets at the start of a migraine attack. If your symptoms continue, take two further tablets or sachets after four hours, and a further two tablets or sachets four hours later if necessary. Do not take more than six tablets or six sachets in any 24-hour period.

Can Reglan be used for migraines?

While metoclopramide (Reglan) is sometimes recommended as a single agent in the treatment of migraine pain, its main use is for treating accompanying nausea and improving gastric motility, which may be impaired during migraine attacks. Prochlorperazine (Compazine) can effectively relieve headache pain.

What is the best medicine for migraine headache?

Which OTC drugs are commonly recommended to treat migraine headaches? NSAIDS — or nonsteroidal anti-inflammatory drugs — are the first line of treatment when it comes to migraines. These include ibuprofen, which is known by the brand names of Motrin and Advil; and naproxen, which is known as Aleve.

Who should not take metoclopramide?

You also should not use metoclopramide if you’ve had stomach or intestinal problems (a blockage, bleeding, or a hole or tear), epilepsy or other seizure disorder, or an adrenal gland tumor (pheochromocytoma). NEVER USE METOCLOPRAMIDE IN LARGER AMOUNTS THAN RECOMMENDED, OR FOR LONGER THAN 12 WEEKS.

Is Reglan a serotonin antagonist?

Metoclopramide is principally a dopamine D2 antagonist but also acts as an agonist on serotonin 5-HT4 receptors and causes weak inhibition of 5-HT3 receptors.

What is the best medicine for migraine relief?

Beta blockers, which are commonly used to treat high blood pressure and coronary artery disease, may reduce the frequency and severity of migraines. The beta blockers propranolol (Inderal LA, Innopran XL, others), metoprolol tartrate (Lopressor) and timolol (Betimol) have proved effective for preventing migraines.

What drugs cause migraine?

“Certain cardiac medicines, especially any related to the nitrates, nitroglycerin, or even a nitro patch for angina all can precipitate a migraine,” Diamond says.

What medications treat migraine headaches?

Acetaminophen (Tylenol, others), also may help relieve mild migraines in some people. Drugs marketed specifically for migraines, such as the combination of acetaminophen, aspirin and caffeine (Excedrin Migraine), also may ease moderate migraine pain.