Is carboplatin as effective as cisplatin?
Conclusions: For some tumors, cisplatin appears to be superior to carboplatin in terms of therapeutic effectiveness (germ cell tumors, bladder cancer, head and neck cancer), while for others, effectiveness is comparable (lung cancer, ovarian cancer).
What are the advantages of carboplatin over cisplatin?
Meta-analyses of palliative chemotherapy indicate consistent survival advantages with cisplatin-based therapy over carboplatin; however, the relative advantage is small. Cisplatin carries a higher toxicity profile, including nausea, vomiting, neuropathy, renal insufficiency, and alopecia in comparison to carboplatin.
Why is carboplatin less toxic than cisplatin?
Carboplatin is primarily eliminated through the kidneys. Its elimination is slower than cisplatin with a terminal half-life between 2 and 6 hours. After IV injection, approximately 60% of the total drug is excreted within 24 hours.
Is carboplatin safer than cisplatin?
Cisplatin and carboplatin have different toxicity profiles; cisplatin is associated with a higher rate of nausea, vomiting, nephrotoxicity, ototoxicity, while carboplatin has a higher risk of myelosupresssion and neurotoxicity6.
Is carboplatin effective on its own?
Any effect carboplatin has is usually mild and will get better by itself.
Is carboplatin more toxic than cisplatin?
What is cisplatin and carboplatin?
Cisplatin and carboplatin, represent some of the most active cytotoxic agents and are the backbone of most chemotherapeutic regimens. • Despite their relative similarities in mechanisms of action, there are significant differences in efficacy and toxicity in various malignancies.
Will I lose my hair on carboplatin?
Your hair may get thinner. But you are unlikely to lose all the hair from your head. Hair loss usually starts after your first or second treatment. It is almost always temporary, and your hair will usually grow back after treatment finishes.
Does cisplatin cause ototoxicity?
Cumulative renal toxicity associated with Cisplatin is severe. Other major dose-related toxicities are myelosuppression, nausea, and vomiting. Ototoxicity, which may be more pronounced in children, and is manifested by tinnitus, and/or loss of high frequency hearing and occasionally deafness, is significant.
How is cisplatin made?
The synthesis of cisplatin starts from potassium tetrachloroplatinate. The tetraiodide is formed by reaction with an excess of potassium iodide. Reaction with ammonia forms K2[PtI2(NH3)2] which is isolated as a yellow compound.
How carboplatin was developed?
How Carboplatin Was Developed Building on the success of cisplatin, Dr. Barnett Rosenberg and his team at Michigan State University got to work developing a “second generation” drug. The result was carboplatin, which is a modified form of, and worked in largely the same way as, cisplatin.