How does obatoclax work?

How does obatoclax work?

Obatoclax (GX) inhibits autolysosome cargo by degrading cathepsin D and L protein expression. Anti-estrogen sensitive, LCC1, and resistant, LCC9, cells were seeded in 6-well plates 24 hours before treatment with the 100 nM GX.

Does bortezomib cause hair loss?

Hair loss. Hair loss isn’t a direct side effect of Velcade, but it may be a side effect of other drugs used with Velcade. For example, hair loss may occur in people using Velcade with cyclophosphamide, which is a cytotoxic drug. (Cytotoxic drugs work by killing cells.)

How is Cybord administered?

How Is This Treatment Given? Bortezomib is given under your skin using a small needle (subcutaneous or Subcut) or through an IV (injected into a vein). This is done at the hospital. You will have a blood test before each treatment cycle to make sure it is safe for you to get treatment.

Can I color my hair while on chemotherapy?

Chemotherapy renders hair extremely fragile. As medication and treatments take effect, the body weakens. A side-effect commonly linked to chemotherapy is hair loss and lack of regrowth, as hair no longer gets vital nutrients. Doctors and oncologists discourage coloring with conventional hair dye during chemotherapy.

Is Cybord chemotherapy?

CyBorD (Cyclophosphamide + Bortezomib + Dexamethasone) is a Chemotherapy Regimen for Multiple Myeloma (MM)

What is Cybord therapy?

What Is This Treatment? CYBORD is the code name of your multiple myeloma treatment regimen. A regimen is a combination of medications to treat cancer. This regimen name is made up of 1 or more letters from the names of the 3 medications in your treatment.

How do you take care of a bald head during chemo?

Moisturize, Moisturize, Moisturize Your Bald Head When going through chemo, try to keep your skin in the best shape possible by applying moisturizer. Opt for an ointment or cream as they’re usually thicker than lotion. Apply it soon after getting out of the shower so your scalp doesn’t have a chance to dry out.

What are the strongest chemo drugs?

Doxorubicin (Adriamycin) is one of the most powerful chemotherapy drugs ever invented. It can kill cancer cells at every point in their life cycle, and it’s used to treat a wide variety of cancers.

Is Obatoclax a BCL antagonist?

Bcl family members Bcl-2, Bcl-x (L), and Mcl-1, are frequently expressed and implicated in the survival of myeloma cells. Obatoclax (GX015-070) is a novel, small-molecule antagonist of the BH3-binding groove of the Bcl family of proteins.

How does obobatoclax work?

Obatoclax (GX015-070) is a novel, small-molecule antagonist of the BH3-binding groove of the Bcl family of proteins. We show that GX015-070 inhibits the binding of Bak to Mcl-1, up-regulates Bim, induces cytochrome c release, and activates capase-3 in human myeloma cell lines (HMCLs), confirming the predicted mechanism of action.

How does Obatoclax interact with carfilzomib?

Obatoclax, which both disrupts the function of Mcl-1 (37) and triggers up-regulation of Noxa (38), a protein capable of down-regulating Mcl-1 (30), potentiates bortezomib lethality in multiple myeloma, mantle cell lymphoma, and other models (17) (19, 20). Here, carfilzomib alone up-regulated Mcl-1, an event prevented by obatoclax co-administration.

Does Obatoclax induce autophagy?

Obatoclax induces an autophagy response in various malignant hematopoietic cells, including myeloma and leukemia (33, 45). In DLBCL cells, obatoclax induced autophagy by itself, but this phenomenon was not potentiated by carfilzomib.