What is stage II thymoma?
Stage II. In stage II, cancer has spread through the capsule and into the fat around the thymus or into the lining of the chest cavity. Stage III. In stage III, cancer has spread to nearby organs in the chest, including the lung, the sac around the heart, or large blood vessels that carry blood to the heart.
What is metastatic thymic cancer?
The metastatic tumor is the same type of cancer as the primary tumor. For example, if thymic carcinoma spreads to the bone, the cancer cells in the bone are actually thymic carcinoma cells. The disease is metastatic thymic carcinoma, not bone cancer.
Can thymic carcinoma spread?
Thymomas are generally slow-growing tumors. Occasionally, it can spread to the lining of the lung, called the pleura. Less often, it can spread to other parts of the body. Thymic carcinoma (see Stages) also starts in the thymus.
What is Stage 4A thymoma?
Stage 4A. The cancer has spread to lymph nodes around the thymus (perithymic lymph nodes) or the cancer has spread to a part of the pleura or pericardium that is not attached to the main tumour.
How long do you live with thymic carcinoma?
5-year relative survival rates for thymus cancer
|SEER Stage||5-Year Relative Survival Rate|
|All SEER stages combined||71%|
How long can you live with thymic carcinoma?
Can thymic carcinoma spread to brain?
Although uncommon, patients with advanced thymic carcinoma can develop brain metastases. Appropriate imaging and aggressive treatment should be considered for these patients.
How fast does thymus cancer grow?
There are 2 main types of thymus tumors. Your doctor can tell you more about the kind you have. Thymomas tend to grow slowly and rarely spread to other parts of the body. Thymic carcinomas tend to grow faster and are more likely to spread to other parts of the body.
How close is the thymus to the heart?
The thymus sits just in front of and above the heart. The thymus is divided into 2 halves, called lobes. It has an irregular shape. There are a lot of small bumps called lobules on its surface.
Is Amrubicin effective in the treatment of thymic malignancies?
Amrubicin shows promise as a single agent in heavily pre-treated patients with thymic malignancies. Notable side effects include febrile neutropenia and the use of growth factor support is essential. Further investigation of this agent is warranted. Amrubicin shows promise as a single agent in heavily pre-treated patients with thymic malignancies.
What is Amrubicin anthracycline?
Amrubicin is a third-generation synthetic anthracycline currently in development for the treatment of small cell lung cancer. Pharmion licensed the rights to Amrubicin in November 2006. In 2002, Amrubicin was approved and launched for sale in Japan based on Phase 2 efficacy data in both SCLC and NSCLC.
What is the mechanism of action of Amrubicin?
As an anthracycline, amrubicin has antimitotic and cytotoxic activity through a variety of mechanisms of action.
How does Amrubicin inhibit topoisomerase II?
Amrubicin is found to form complexes with DNA via intercalation between base pairs, and it inhibits topoisomerase II enzyme activity by stabilizing the DNA-topoisomerase II complex, which prevents the re-ligation portion of the ligation-religation reaction that topoisomerase II normally catalyzes 11.