What type of transporter is GLUT2?
GLUT2 is the major glucose transporter inβ -cells of pancreatic islets and hepatocytes. In both cell types, GLUT2 mediates the facilitated diffusion of glucose across the cell membranes, and then intracellular glucose metabolism is initiated by the glucose-phosphorylating enzyme, hexokinase IV or glucokinase.
What type of protein is SGLT1?
The SLC5A1 gene provides instructions for producing a protein called sodium/glucose cotransporter protein 1 (SGLT1). This protein is found mainly in the intestinal tract and the kidneys.
Is potassium active or passive transport?
The sodium-potassium pump carries out a form of active transport—that is, its pumping of ions against their gradients requires the addition of energy from an outside source.
Does insulin act on GLUT2?
In pancreatic beta cells, GLUT2 is required for glucose-stimulated insulin secretion. In the nervous system, GLUT2-dependent glucose sensing controls feeding, thermoregulation and pancreatic islet cell mass and function, as well as sympathetic and parasympathetic activities.
Is SGLT1 a channel protein?
If the plasma glucose concentration is too high (hyperglycemia), glucose passes into the urine (glucosuria) because SGLT are saturated with the filtered glucose….Sodium-glucose transport proteins.
|solute carrier family 5 (sodium/glucose cotransporter), member 1|
What happens to GLUT4 without insulin?
In the absence of insulin, the majority of GLUT4 is stored in small intracellular vesicles [referred to as GLUT4 storage vesicles (GSVs) (Martin et al., 1998) or insulin responsive vesicles (IRVs) (Kupriyanova et al., 2002)].
Does insulin bind to GLUT4?
GLUT4 is stored in the cell in transport vesicles, and is quickly incorporated into the plasma membrane of the cell when insulin binds to membrane receptors.