Why should platelets not be cross matched?
A cross-match is usually not needed for a platelet or plasma transfusion unless the platelets look like they could contain some red blood cells.
Does platelet transfusion need cross match?
Platelet transfusions from RhD-positive donors to recipients with anti-D antibodies do not result in hemolysis, because they contain very few RBCs. Only products containing >2 mL of incompatible RBCs require a serologic crossmatch per AABB standards.
Does platelet transfusion require same blood group?
Platelets express ABO antigens and are collected in plasma, which contains ABO antibodies as would be consistent with the donor ABO group. Platelet ABO antigens that are incompatible with recipient ABO antibodies may have accelerated clearance from circulation and result in lower count increments.
What are the risks of platelet transfusion?
Common side effects of platelets include:
- Hemolytic transfusion reactions.
- Febrile non-hemolytic reactions.
- Allergic reactions ranging from hives to severe (anaphylaxis)
- Septic reactions.
- Transfusion Related Acute Lung Injury (TRALI)
- Circulatory overload.
- Transfusion associated graft versus host disease.
Is cross matching required for plasma transfusion?
Because plasma from donors with type AB blood does not contain anti-ABO antibodies, it can be given to any patient and is used for emergency transfusion in patients with unknown blood types. Crossmatching of plasma is not required, since there are no RBCs in these products.
Does blood group matter for platelet donation?
Platelets are not as type specific as red blood cells, meaning that most patients can accept platelets from donors with any blood type, regardless of the patient’s blood type.
What is the cross-matching protocol for platelets?
A platelet cross-matching procedure has been assessed for selecting compatible donors for alloimmunized patients. This confirms the clinical value of combining an indirect platelet immunofluorescence test (PIFT) with a lymphocytotoxicity test (LCT) in predicting the survival of single-donor platelets.
Is it safe to donate platelets?
How safe is donating platelets? Donating platelets is a safe process. Platelet donations are performed in a highly-controlled environment by professionally trained staff. Each donation is collected through a new, sterile needle that is used once and then discarded.
Does FFP require cross-matching?
FFP transfusions must be ABO compatible, but Rh compatibility and cross-matching are not required (Table 35.1).
Why can’t o negative donate platelets?
On the other end of the blood spectrum, O-negative donors are strongly discouraged from giving platelets. Just as AB+ is the universal blood type for platelets, O neg is the universal blood type for red cells. Just 7% of the population has O- blood, so that’s why O- donors should always give red blood cells.
Can platelet cross-matching predict transfusion response?
By using multivariate analysis, platelet cross-matching was found to be the best predictor of transfusion response, followed by clinical factors and alloimmunisation, at 1 hour.
What is plaqueplatelet cross-matching?
Platelet cross-matching using the solid-phase red cell adherence technique is an effective and rapid first-line approach for the management of patients refractory to platelet transfusions.
Do incompatible blood transfusions affect platelet count increments?
Recent findings: ABO-major incompatible transfusions are associated with lower platelet count increments than either ABO identical or minor incompatible transfusions and may lead to decreased intervals between platelet transfusions in thrombocytopenic patients.
Are dondonor platelets cross-match-compatible?
Donor platelets lacking reactivity in the assay are considered to be “cross-match-compatible” and are selected for transfusion support 22. Selection of products based on platelet cross-matching has been shown to improve post-transfusion platelet increments in refractory patients 11,23–25.