How much oxycodone is equivalent to hydrocodone?
Table 1. Opioid Equi-analgesic Doses
| Opioid Agonist | Parenteral Dose, IV, SC, IM | Oral Dose |
|---|---|---|
| HYDROmorphone (Dilaudid) | 1.5 mg | 7.5 mg |
| OXYcodone (Oxecta) | – | 15-20 mg |
| OXYcodone, long-acting (OxyContin) | – | 20 mg |
| HYDROcodone (Vicodin, Lortab) | – | 30-45 mg |
Is OxyContin stronger than morphine?
yes oxy is stronger than morphine sulphate. My take on the question is that a mg-for-mg comparison is being requested so this reply doesn’t really help. Also, we wouldn’t be on this site if we wanted (or felt able/confident) to ask our doctor.
What is the morphine equivalent of OxyContin?
Use of Oral Methadone for Chronic Pain. The total daily dose of oxycodone is 240 mg daily. The next step is to convert 240 mg of oral oxycodone to the daily oral morphine equivalent dose (DOMED). The equianalgesic chart indicates that 20 mg of oral oxycodone is equal to 30 mg of oral morphine.
What narcotics are similar to OxyContin?
Oxycodone ( OxyContin, Oxaydo, Xtampza ER, Roxybond) and hydrocodone ( Zohydro ER) are strong prescription opioid (narcotic) pain relievers similar to morphine, fentanyl, and methadone.
How strong is oxycodone compared to morphine?
In medical literature, the analgesic strength, or potency, of most painkillers is measured as a comparison to morphine. For example, oxycodone is roughly 50 percent stronger than morphine. Therefore, researchers might say the drug is 1.5 times as strong as morphine.
How do you convert opioid doses?
Determine equivalent daily dose of new opioid by dividing the calculated MMEs of current opioid by new opioid’s conversion factor. Reduce this amount by 25-50% and then divide into appropriate intervals.
What is hydrocodone converted to?
Hydrocodone is transformed to hydromorphone through O-demethylation catalyzed by the cytochrome P450 (CYP450) enzyme CYP2D6, influencing the metabolism of 25% of all drug therapies (Cone et al., 1978). FIGURE 1. Metabolic conversion of hydrocodone to hydromorphone.
What receptor does hydrocodone bind to?
Hydrocodone primarily binds and activates the mu-opioid receptor in the CNS and possesses analgesic and antitussive effects. Binding of hydrocodone to this receptor also results in analgesia, euphoria, respiratory depression, decreased gastrointestinal motility and physical dependence.
What does Hydro stand for in hydrocodone?
Listen to pronunciation. (HY-droh-KOH-done by-TAR-trayt)
What is the formula for hydrocodone?
C18H21NO3Hydrocodone / Formula