What medications can cause osteonecrosis of the jaw?
Bisphosphonates — such as alendronate (Fosamax, Binosto), risedronate (Actonel, Atelvia), ibandronate (Boniva) and zoledronic acid (Reclast, Zometa) — and denosumab (Prolia, Xgeva) have been linked to osteonecrosis of the jaw and atypical femoral fractures.
Which drugs cause MRONJ?
Drugs with the highest risk of causing MRONJ were the bisphosphonates, particularly pamidronate (approximately 500 times greater risk compared to no exposure) and zoledronate (approximately 170 times greater risk). The RANKL inhibitor denosumab showed a 14% greater risk.
What is medication-related osteonecrosis?
Medication-related osteonecrosis of the jaw (MRONJ) is a rare, severe debilitating condition from unknown causes. It is characterized by nonhealing exposed bone in a patient with a history of antiresorptive or antiangiogenic agents in the absence of radiation exposure to the head and neck region.
Which of the following drug therapies is associated with a rare complication of osteonecrosis of the jaw?
Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious adverse effect of bone antiresorptive agents (i.e., bisphosphonates, denosumab) used for osteoporosis.
Who should not take Prolia?
Denosumab has proven effective at building bone density and reducing spine and hip fractures. However, it carries a risk of serious side effects. People with weakened immune systems are advised not to use to denosumab because it can lead to serious infections that require hospitalization (such as heart infections).
How do you treat osteonecrosis of the jaw?
Osteonecrosis of the jaw is usually treated with antibiotics, oral rinses, and removable mouth appliances (retainers). Because osteonecrosis of the jaw is rare, doctors can’t predict who will develop it. If you’re taking a bisphosphonate, tell your dentist right away.
Does Prolia cause weight gain?
Weight gain itself wasn’t reported as a side effect during clinical trials of Prolia. However, some people taking Prolia did have swelling in their arms or legs. And with swelling, your body weight can be quickly increased.
Can you have dental work done while on Prolia?
Based on their findings, Watts and colleagues recommend that “management of subjects with osteoporosis receiving denosumab should include routine dental care and treatment, including scaling/root planing when indicated, since nearly 30% of subjects reported receiving this procedure and none developed ONJ as a result.”
Is Prolia worth the risk?
Are there any dangers of using this drug? Studies have found that Prolia is generally safe and effective to treat osteoporosis and certain types of bone loss. For example, in the studies, people taking Prolia for up to 8 years didn’t have significant side effects compared with people taking a placebo.
What is medication-related osteonecrosis of the jaw (MRONJ)?
Medication-related osteonecrosis of the jaw (MRONJ) is a severe adverse drug reaction, consisting of progressive bone destruction in the maxillofacial region of patients.
What is bisphosphate-associated osteonecrosis of the jaw (bonj)?
There is increasing awareness of these drugs’ possible adverse side effect of Bisphosphate-associated Osteonecrosis of the Jaw (BONJ). This is a severe adverse drug reaction, consisting of progressive bone destruction in the maxillofacial region of the patient.
What dental procedures increase the risk of osteonecrosis of the jaw?
Surgical procedures such as tooth extractions, endodontic surgical procedures or placement of dental implants appear to pose an increased risk for developing osteonecrosis of the jaws and should be avoided if possible.
What are the treatment options for osteonecrosis of the mouth?
An orthopantomography every 6–12 months for radiographic evidence of osteonecrosis should be performed. Teeth with mobility Grades 1–2 should be splinted whereas teeth with mobility Grade 3 should be extracted with minimum bone injury. An antibiotic prophylaxis for surgery procedures is necessary.