When is CroFab indicated?
CROFAB is indicated for the management of adult and pediatric patients with North American crotalid envenomation. The term crotalid is used to describe the Crotalinae subfamily (formerly known as Crotalidae) of venomous snakes which includes rattlesnakes, copperheads and cottonmouths/water moccasins.
Can you get CroFab more than once?
If initial control is not achieved by the first dose, an additional dose of 4 to 6 vials should be repeated until initial control of the envenomation syndrome has been achieved. After initial control has been established, additional 2-vial doses of CROFAB every 6 hours for up to 18 hours (3 doses) is recommended.
What does CroFab stand for?
CROFAB [Crotalidae Polyvalent Immune Fab (Ovine)] is a sterile, nonpyrogenic, purified, lyophilized preparation of ovine Fab (monovalent) immunoglobulin fragments obtained from the blood of healthy sheep flocks immunized with one of the following North American snake venoms: Crotalus atrox (Western Diamondback …
What is CroFab made of?
CroFab is composed of several monovalent Fragment antigen-binding proteins (Fab) derived from the blood of sheep immunized with one of four snake venom: Crotalus atrox (western diamondback rattlesnake), Crotalus adamanteus (Eastern diamondback rattlesnake), Crotalus scutulatus (Mojave rattlesnake), or Agkistrodon …
What does CroFab treat?
Crotalidae antivenin is an anti-venom used to treat a person who has been bitten by a venomous snake such as a rattlesnake or Water Moccasin. CroFab may also be used for purposes not listed in this medication guide.
Is CroFab covered by insurance?
We also heard from a WakeMed patient treated with anti-venom after a copperhead bite. Her bill, just for the anti-venom, was $39,000 before insurance. We called the manufactures of CroFab, BTG. Depending on the plan, most insurance companies cover a portion of the anti-venom.
Does CroFab work for Copperheads?
New Study Shows Patients Treated With CroFab® Have Improved Recovery From Copperhead Envenomation.
How much is a vial of CroFab?
Today, the list price for wholesalers for the medicine is $3,198 a vial, and the recommended starting dose is four to six vials. CroFab generated more than $132 million in revenue for BTG, according to the company’s 2019 annual report. It represented 14% of total revenue.
Who manufactures CroFab?
Manufacturer: Protherics Inc.
Is CroFab made with horse serum?
Although the horse is most common, CroFab is ovine-derived, meaning it comes from sheep. This has important clinical implications, because sheep serum is less likely to elicit an allergic reaction than horse serum, which contains a highly immunogenic immunoglobulin G subclass.
How much does a vial of CroFab cost?
Having the market all to itself, CroFab has quadrupled in price since its launch, according to data from the health technology company Connecture. Today, the list price for wholesalers for the medicine is $3,198 a vial, and the recommended starting dose is four to six vials.
Does insurance cover CroFab?