Is drug receptor binding selective?

The binding can be specific and reversible. A ligand may activate or inactivate a receptor; activation may increase or decrease a particular cell function. Each ligand may interact with multiple receptor subtypes. Few if any drugs are absolutely specific for one receptor or subtype, but most have relative selectivity.

What is an inhibitor receptor?

Inhibitory receptors in general do not function on their own but regulate the strength of the signal of activating receptors. With few exceptions, inhibitory receptors relay their inhibitory signal through one or more immunoreceptor tyrosine-based inhibitory motifs (ITIMs) present in their cytoplasmic domains.

What is the difference between drug selectivity and specificity?

For example a selective drug would have the ability to discriminate between, and so affect only one cell population, and thereby produce an event. Specificity, a term most often confused with selectivity, will be used to describe the capacity of a drug to cause a particular action in a population.

What are the 4 types of drug receptors?

Receptors can be subdivided into four main classes: ligand-gated ion channels, tyrosine kinase-coupled, intracellular steroid and G-protein-coupled (GPCR). Basic characteristics of these receptors along with some drugs that interact with each type are shown in Table 2.

What is KD in pharmacology?

The dissociation constant, KD, is the concentration at which 50% of the binding sites (receptors) are occupied by the drug. Occurs when an antagonist binds to the receptor in a site different from the binding site of the agonist.

Which type of cell is important in inhibiting lymphocytes?

Regulatory T cells (or Tregs) help to suppress the immune system. Lymphocytes are immune cells found in the blood and lymph tissue. T and B lymphocytes are the two main types.

What has an inhibitory effect on B lymphocytes?

Inhibitory receptors are involved in this regulation, a number having been shown to be critical in controlling the B cell immune response. There are two broad classes of inhibitory receptor − most are of the immunoglobulin (Ig) superfamily while the remainder are lectin-like molecules.

Why is drug selectivity important?

Drug selectivity is an important aspect for evaluating the ADRs of drugs, and there is evidence that compound target promiscuity is largely correlated with its lipophilicity and ionization states. It is widely agreed that drug attrition is closely related with its ADMET properties.

What is selective and non selective drugs?

Selectivity is the degree to which a drug acts on a given site relative to other sites. Relatively nonselective drugs affect many different tissues or organs. For example, atropine, a drug given to relax muscles in the digestive tract, may also relax muscles in the eyes and in the respiratory tract.

What happens when an agonist binds to a receptor?

An agonist binds to the receptor and produces an effect within the cell. An antagonist may bind to the same receptor, but does not produce a response, instead it blocks that receptor to a natural agonist.