How does discodermolide work?
(+)-Discodermolide arrests cell cycle via binding and stabilization of the microtubule network. Hyper-stabilization of the mitotic spindle causes cell cycle arresting at G2 and M phase and eventually leads to cell death by apoptosis.
Where is discodermolide found?
Discodermolide (3) is a polypropionate-based unique compound isolated from the Caribbean deep-sea sponge Discodermia dissoluta. It is immunosuppressive as well as highly cytotoxic.
What is the maximum number of stereoisomers possible for Discodermolide?
Discodermolide has 13 chiral carbons and two geometrical centres which means the number of stereoisomers for discodermolide ${2^{15}}$. Therefore, the option B is correct. Note: If there is restricted rotation in a molecule there arises geometric isomerism. Geometric isomers are also known as Cis- trans isomerism.
How was bryostatin discovered?
The first bryostatins were discovered using an antineoplastic bioassay-guided fractionation approach [2]. Bryostatins are present in very low amounts in B. neritina colonies: nearly all of the bryostatins were isolated at a yield of 10−5 and 10−7 % B.
What is the maximum number of stereoisomers possible for the following structure?
The maximum number of stereoisomers is 2n , where n is the number of chiral carbons. Since n=3 and 23=8 , there are eight possible aldopentoses.
What is the maximum possible number of stereoisomers in the set that includes the structure shown?
The maximum number of stereoisomers that a molecule can have is 2n , where n is the number of chiral centres. A molecule with three chiral centres will have 23=8 stereoisomers.
Who discovered bryostatin?
George Pettit
Bryostatin 1 was first isolated in the 1960s by George Pettit from extracts of a species of bryozoan, Bugula neritina, based on research from samples originally provided by Jack Rudloe to Jonathan L. Hartwell’s anticancer drug discovery group at the National Cancer Institute (NCI).
What is bryostatin made from?
Bryostatins are naturally occurring antineoplastic macrocyclic lactones derived from the marine invertebrate Bugula neritina, different varieties being isolated from different populations of the same species.
How many D Aldopentoses are possible?
eight
There are eight possible stereoisomers of the aldopentoses.
How many stereoisomers can exist?
The maximum number of stereoisomers that a molecule can have is 2n , where n is the number of chiral centres. A molecule with three chiral centres will have 23=8 stereoisomers. For example, the aldopentoses all have three chiral carbons, and there are eight stereoisomers.
What is bryostatin used for?
Bryostatins are potent modulators of protein kinase C. They have been studied in clinical trials as anti-cancer agents, as anti-AIDS/HIV agents and in people with Alzheimer’s disease.
What are the 5 pentose sugars?
The pentoses, ribose, deoxyribose, and ribitol are also monosaccharides but are not thought of as major sources of dietary energy. They are called “pentoses” because, unlike glucose, fructose, and galactose, they are comprised of a five-carbon backbone rather than a six-carbon backbone.