How do dendritic cells recognize antigens?

Dendritic cells identify antigens via pathogen-associated molecular patterns (PAMPS) or damage-associated molecular patterns (DAMPs). Comprised of molecules common to a variety of organisms but absent in the host, PAMPS are an exogenous signal to dendritic cells for infection.

What MHC is on dendritic cells?

Dendritic cells (DCs) and B cells present antigen-derived peptides bound to MHC class II (MHC II) molecules for recognition by CD4-positive T lymphocytes. DCs control the intracellular traffic of peptide–MHC II complexes by regulating the ubiquitination of MHC II.

Why do dendritic cells do cross presentation?

Cross-presentation is of particular importance, because it permits the presentation of exogenous antigens, which are normally presented by MHC II on the surface of dendritic cells, to also be presented through the MHC I pathway.

How do dendritic cells develop into antigen-presenting cells *?

Dendritic cells (DCs) are uniquely potent in orchestrating T cell immune response, thus they are indispensable immune sentinels. They originate from progenitors in the bone marrow through hematopoiesis, a highly regulated developmental process involving multiple cellular and molecular events.

How do dendritic cells capture and present protein antigens?

In this study, we have shown that mature DCs, even as they down-regulate constitutive macropinocytosis and phagocytosis, retain the ability to capture antigens via receptor-mediated endocytosis. In addition, these captured antigens are presented on MHC molecules with high efficiency both in vitro and in vivo.

Do B cells express MHC I?

All professional APCs also express MHC class I molecules as well. The main types of professional antigen-presenting cells are dendritic cells, macrophages and B cells.

Do dendritic cells express MHC class 1?

Dendritic cells (DCs) have the unique ability to pick up dead cells carrying antigens in tissue and migrate to the lymph nodes where they can cross-present cell-associated antigens by MHC class I to CD8+ T cells. There is strong in vivo evidence that the mouse XCR1+ DCs subset acts as a key player in this process.

Do dendritic cells have MHC class I and II?

MHC I are found on all nucleated body cells, and MHC II are found on macrophages, dendritic cells, and B cells (along with MHC I).

Do dendritic cells express MHC Class 2?

Dendritic cells (DCs), B cells and macrophages constitutively express MHC class II molecules and are regarded as the ‘professional’ antigen-presenting cells (APCs) of the immune system (Fig. 1).