What are histiocytic neoplasm?
Histiocytic neoplasms represent hematologic disorders characterized by the accumulation of myeloid-dendritic cell-derived neoplastic cells with an accompanying inflammatory infiltrate. 1,2. They are rare, accounting for less than 1% of cancers of the soft tissue and lymph nodes.
What is sarcoma of dendritic cells?
Follicular dendritic cell sarcoma (FDCS) is a rare low-grade sarcoma that most commonly presents as a slowly growing, painless mass with the histologic appearance of spindle-shaped cells in a whorled pattern. Several hundred cases have been reported since it was first described in 1986 [1].
How is histiocytic sarcoma treated?
NAVIGATING THROUGH MY OPTIONS
| Treatment | Indication |
|---|---|
| Chemotherapy: Doxorubicin | Disseminated disease, post-operatively for localized disease, hemophagocytic histiocytic sarcoma |
| Chemotherapy: Zoledronate (bisphosphonate) | All cases receiving chemotherapy |
| Radiation Therapy: Definitive | Incompletely excised localized tumors |
Are dendritic cells histiocytes?
The histiocyte is a tissue macrophage or a dendritic cell (histio, diminutive of histo, meaning tissue, and cyte, meaning cell).
What does histiocytic mean in medical terms?
Medical Definition of histiocytosis : abnormal multiplication of macrophages Langerhans cell histiocytosis broadly : a condition characterized by such multiplication.
How rare is follicular dendritic sarcoma?
Abstract: Follicular dendritic cell sarcoma (FDCS) is a rare malignant tumor recognized in recent years. It accounts for only 0.4% of soft-tissue sarcomas, and its underlying causes are largely unknown.
What causes histiocytic sarcoma in humans?
Histiocytic sarcoma is a rare histiocytic neoplasm that can arise as a result of transdifferentiation from low-grade B-cell lymphomas, and has a wide differential diagnosis including other histiocytic/dendritic cell neoplasms, myeloid neoplasms, lymphomas, melanoma, and carcinoma.
What causes histiocytic sarcoma?
Histiocytic sarcomas develop when these specialized white blood cells begin dividing uncontrollably. Because white blood cells are found in many different tissues, HS can arise almost anywhere and spread quickly.
What is histiocytic cells?
A histiocyte is a normal immune cell that is found in many parts of the body especially in the bone marrow, the blood stream, the skin, the liver, the lungs, the lymph glands and the spleen. In histiocytosis, the histiocytes move into tissues where they are not normally found and cause damage to those tissues.