What are indoles good for?
A type of chemical found in plants and in certain vegetables, such as broccoli, cabbage, and cauliflower. Indoles may promote good health and are being studied in the prevention of certain types of cancer, including breast cancer, prostate cancer, and colon cancer.
How do I get more indoles?
Rich Sources. Research suggests that eating a diet rich in fruits, vegetables and cereal grains may help to reduce your risk of cancer and other diseases. Cruciferous vegetables provide a rich indole source. These include Brussels sprouts, broccoli, bok choy, cabbage and turnips.
What is Diindolylmethane used for?
Diindolylmethane is used for preventing breast, uterine, and colorectal cancer. It is also used to prevent an enlarged prostate (benign prostatic hypertrophy, BPH) and treat premenstrual syndrome (PMS).
What does indoles mean?
Definition of indole : a crystalline alkaloid compound C8H7N that is a decomposition product of proteins containing tryptophan, that can be made synthetically, and that is used in perfumes also : a derivative of indole.
What are the side effects of DIM?
Current human research doesn’t show DIM supplements to be toxic or have serious side effects. The most common side effects include darkening of the urine, an increase in bowel movements, headaches, and gas ( 3 , 8 ). Less common side effects include nausea, vomiting, diarrhea, and skin rash ( 3 ).
Can diindolylmethane cause weight gain?
DIM Stimulates Fat Breakdown DIM is associated directly with estrogen metabolism, which is essential in regulating body weight. Studies show that estrogen imbalances correspond with weight gain for both men and women, particularly during menopause and andropause when estrogen levels are the most inconsistent.
What are the side effects of taking DIM?
How do bacteria produce indoles?
Tryptophan is an amino acid that can undergo deamination and hydrolysis by bacteria that express tryptophanase enzyme. Indole is generated by reductive deamination from tryptophan via the intermediate molecule indolepyruvic acid.
What are the essential phytochemicals for humans?
2.5 Essential Phytochemicals Phytochemicals are precious for human nutrition. Indoles, isothiocyanates, and sulforaphane from vegetables, such as broccoli, alylic sulfides from onions and garlic and isoflavonoids from soybeans are known as plant phytochemicals.
What are phytochemicals in fruits and vegetables?
Phytochemicals are defined as bioactive nutrient plant chemicals in fruits, vegetables, grains, and other plant foods that may provide desirable health benefits beyond basic nutrition to reduce the risk of major chronic diseases (Liu, 2004). From: Therapeutic Foods, 2018
How do phytochemicals interact with CYP450?
Phytochemicals interact with CYP450 as substances to be metabolized, and select phytochemicals are also capable of inducing and/or inhibiting specific or multiple CYP enzymes. Naturally, the abundance of specific CYP enzymes varies by ethnicity and also by individuals.
Are phytochemicals good or bad for You?
Preclinical, clinical, and epidemiological research suggests that phytochemicals may be effective in treating various diseases owing to their antioxidant and antiinflammatory activities. On the other hand, consumption of certain phytochemicals may cause some acute and chronic toxic effects and may even cause the development of cancer.