What is prothrombin complex used for?
Prothrombin complex human contains coagulation factors II, VII, IX, and X, and proteins C and S. This medicine is used to stop bleeding by helping the blood to clot. This medicine is to be given only by or under the supervision of your doctor.
How does prothrombin complex concentrate work?
Medical uses. Prothrombin complex concentrate reverses the effects of warfarin and other vitamin K antagonist anti-coagulants and is used in cases of significant bleeding in people with a coagulopathy. It is also used when such a person must undergo an emergency operation treatment.
What does prothrombin complex concentrate contain?
It is a balanced concentrate, containing a defined concentration of the four vitamin K-dependent clotting factors (II, VII, IX and X) and the thrombo-inhibitor proteins C and S. Interestingly, it is the only PCC containing antithrombin in addition to heparin.
Is Octaplex a blood product?
Octaplex belongs to a group of medicines called clotting factors. It contains the human vitamin K dependent blood coagulation factors II, VII, IX and X. used when purified specific clotting factor product is not available. in your blood.
How long does prothrombin complex take to work?
It usually reverses warfarin anticoagulation within 10-30 minutes.
How is prothrombin complex made?
Prothrombin complex concentrate (PCC) comes from the process of ion-exchange chromatography from the cryoprecipitate supernatant of large plasma pools and after removal of antithrombin and factor XI.
What is four factor prothrombin complex concentrate?
The 4-factor prothrombin complex concentrate (4F-PCC), which contains the human coagulation factors II, VII, IX and X together with the endogenous inhibitor proteins S and C, is indicated for the urgent reversal of acquired coagulation factor deficiency induced by VKA (e.g. warfarin or coumarin) therapy in adult …
How do you administer prothrombin complex concentrate?
Dosing of prothrombin complex concentrate should be based on the INR as per the table below. If the INR is unknown and maor bleeding is present 80 mL should be administered. Administration: Must be administered intravenously. May be administered by direct IV push, syringe pump or minibag.
How long does it take for Octaplex to work?
The correction of the vitamin K antagonist induced impairment of haemostasis persists for approximately 6-8 hours. However, the effects of vitamin K, if administered simultaneously, are usually achieved within 4-6 hours.
Why is Octaplex used?
Octaplex is a new prothrombin complex concentrate that is indicated for treatment or perioperative prophylaxis of bleeding in patients with deficiency of the prothrombin complex coagulation factors, such as deficiency caused by treatment with vitamin K antagonists or by liver failure, when rapid correction of bleeding …
How is prothrombin complex administered?
Beriplex® P/N should be administered intravenously at no more than 3 IU/kg/min (max 210 IU/min). A syringe driver should be used if available. The maximum single dose should NOT exceed 5000 IU factor XI. Primary measure of haemostatic efficacy is correction of INR.
Why is Vit K given PCC?
PCC will reverse anticoagulation within minutes of administration; FFP administration can take hours due to the volume required; vitamin K effect takes 12 to 24 hours, but administration of vitamin K is needed to counteract the long half-life of warfarin.