What is BerEp4 positive?

BerEp4 has a high sensitivity and specificity in being positive only in BCC cells. BerEp4 is normally negative in squamous epithelium and mesothelium, but otherwise normally positive most epithelial cells of the body.

What is PAX8 positive?

PAX8-positive, calretinin-negative staining appears to be highly specific and sensitive for detecting metastatic ovarian serous carcinoma in cytological preparations and may prove useful for distinguishing these cells from mesothelial cells in fluid cytology (32).

What does CK20 positive mean?

Positive for CK20 means that the CK20 protein was seen inside the cells of interest in the tissue sample. Reactive is another term that pathologists use to describe cells that are producing CK20.

How do you differentiate between BCC and SCC?

SCC presents as firm, flesh-colored keratotic papules or plaques and smooth nodules. A thick cutaneous horn and ulceration may accompany these lesions. Features that suggest BCC are translucency, ulceration, telangiectasias, pigmentation, and a rolled border.

Are all cancers carcinomas?

Not all cancers are carcinoma. Other types of cancer that aren’t carcinomas invade the body in different ways. Those cancers begin in other types of tissue, such as: Bone.

What does metastatic adenocarcinoma mean?

Adenocarcinoma is a type of cancer that forms in mucus-secreting gland cells, which are found in tissues that line internal organs. When adenocarcinoma spreads from the initial site, it is described as metastatic. ( 1) Metastatic adenocarcinoma can crop up in different parts of the body.

What tumors are positive for PAX8?

These results show that PAX8 is a highly sensitive marker for thyroid, renal, Müllerian, and thymic tumors. Importantly, all lung adenocarcinomas, breast and adrenal neoplasms, and the majority of gastrointestinal tumors were negative for PAX8. Therefore, PAX8 is an excellent marker for confirming primary tumor site.

What does PAX8 negative mean?

PAX8 is considered a negative marker for mesothelioma. This means mesothelioma cancer cells usually do not test positive for PAX8. PAX8 is a common marker for kidney cancer, thyroid cancer and cancers of the female reproductive system.

What is CK7 and CK20 positive?

The CK7-/CK20+ expression pattern is specific for metastatic colorectal carcinomas to the ovary, but has low predictability for colorectal origin in metastatic ovarian carcinoma.

What is CK7 and CK20?

For example, a CK7-negative/CK20-positive phenotype is often associated with carcinomas of colorectal origin, whereas a CK7-positive/CK20-negative phenotype is seen in a wide variety of carcinomas, including carcinomas of the lung, breast, thyroid, pancreas, and female genital tract.

What are squamous cells?

Squamous cells: These are flat cells in the upper (outer) part of the epidermis, which are constantly shed as new ones form. When these cells grow out of control, they can develop into squamous cell skin cancer (also called squamous cell carcinoma).

What do SCC look like?

What does SCC look like? SCCs can appear as scaly red patches, open sores, rough, thickened or wart-like skin, or raised growths with a central depression. At times, SCCs may crust over, itch or bleed. The lesions most commonly arise in sun-exposed areas of the body.

What does BerEp4 stand for?

Definition / general. Antibody to cell membrane glycoproteins expressed on healthy epithelia and in various carcinomas. Also known as epithelial cell adhesion molecule, BerEp4 (Ber-EP4, J Clin Pathol 1990;43:213 ), MOC31 (MOC-31, Acta Neuropathol 1991;83:46 ), CD326, TACSTD1 protein.

Can BerEp4 immunohistochemistry improve the diagnosis of BCC?

Various studies have shown that BerEP4 has a high sensitivity and specificity in detecting only BCC cells. The use of BerEP4 immunohistochemistry testing for the routine examination of cases of BCC is expected to be able to increase and improve early diagnosis as well as prevent recurrence after surgery. 1. Introduction

How is Ber-EP4 antibody made?

The Ber-EP4 antibody was generated using a membrane-enriched fraction derived from the MDF-7 breast cancer cell line. It reacts with an epitope present on two glycoproteins (of 30 and 34 kD respectively)36. Prolonged formalin fixation of more than 48 hours has been reported to lead to loss of antigenicity11, although others have not found this11.

What is monoclonal antibody Ber-EP4 used for in mesothelioma?

“Monoclonal antibody Ber-EP4: its use in the differential diagnosis of malignant mesothelioma and carcinoma in cell blocks of malignant effusions and FNA specimens.” Diagn Cytopathol 10(2): 130-4. 21Shield, P. W., J. J. Callan, et al. (1994).